T lymphocytes targeting native receptors
نویسندگان
چکیده
منابع مشابه
ReviewNuclear Hormone Receptors in T Lymphocytes
469 LSA tive selection) (Jameson et al., 1995). More than 95% of University of California, Berkeley immature double-positive (DP, CD4 CD8 ) thymocytes Berkeley, California 94720 undergo apoptosis. Most of these cells die by a process 2 Howard Hughes Medical Institute known as “death by neglect,” due to sub-threshold or Skirball Institute of Biomolecular Medicine absent interaction of the TCR wi...
متن کاملNuclear Hormone Receptors in T Lymphocytes
Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
متن کاملIdentification of fibronectin receptors on T lymphocytes
We report the identification of fibronectin receptors on thymocytes and T lymphoma cells. Affinity chromatography of extracts of the T cell lymphoma, WR16.1, on a fibronectin-Sepharose column combined with specific elution using a synthetic peptide containing the cell attachment-promoting sequence, arginine-glycine-aspartic acid, yielded two polypeptide components having apparent molecular mass...
متن کاملTargeting of Human Immunodeficiency Virus-Infected Cells by CDS+ T Lymphocytes Armed With Universal T-cell Receptors
We have developed an immunotherapeutic approach with potential application in the treatment of viral and malignant disease. We show that primary CD8' T cells isolated from peripheral blood can be genetically modified by retroviral transduction to express high levels of universal (major histocompatibility complex-unrestricted) chimeric T-cell receptors specific for human immunodeficiency viru...
متن کاملRAPID COMMUNICATION Targeting of Human Immunodeficiency Virus-Infected Cells by CDS+ T Lymphocytes Armed With Universal T-cell Receptors
We have developed an immunotherapeutic approach with potential application in the treatment of viral and malignant disease. We show that primary CD8' T cells isolated from peripheral blood can be genetically modified by retroviral transduction to express high levels of universal (major histocompatibility complex-unrestricted) chimeric T-cell receptors specific for human immunodeficiency viru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2013
ISSN: 0105-2896
DOI: 10.1111/imr.12133